Abiotic and biotic stresses are one of the major threats to food security worldwide and their severity is expected to increase under the projected global warming. As plants cannot escape from unfavourablegrowth conditions, they must continuously cope with these stress factors in the most effective and energy-efficient way. To do so, plants have evolved complex mechanisms to sense and transduce environmental stimuli into adaptive responses. In addition to various sensors and receptors at the plasma membrane, intracellular organelles are recently emerging as key sensors of environmental stresses such as water limitation and pathogen attack. We still lack a profound mechanistic understanding of how organelles communicate and coordinate the complex stress responses. The Inter-organelle Stress Signalling team performs studies to understand the complex organelle-organelle and organelle-to-nucleus cross-talk using high-end multi-omics and cell biology approaches.