Jonas De Backer graduated in 2019 as Master of Bioscience Engineering: Cell and Gene Biotechnology (Bio-engineer) at the faculty of Bioscience Engineering at Ghent University. During his master thesis under the guidance of Prof. Monica Höfte and Dr. Inge De Clercq at the Oxidative Stress Signaling group of Prof. Van Breusegem, he was involved in the study of the post-translational activation of transcription factors involved in retrograde signaling of plant stress responses. On the 1st of January 2020, he started his PhD in the EOS project Retrograde Arabidopsis Chlamydomonas Thiol signaling (ReACTs) to further study this topic while applying for an FWO predoctoral fellowship for fundamental research which he obtained that same year. Now he is doing his joint PhD entitled “Identification of proteases that activate membrane-bound transcription factors during mitochondrial retrograde regulation“ in the inter-organellar signaling lab of Prof. De Clercq in collaboration with the lab of Prof. Monica Höfte (Lab of Phytopathology, Ghent University) and the lab of Prof. Frank Van Breusegem (Lab of Oxidative Stress Signaling, PSB VIB-UGent).

Lindsy graduated with a Master in Biochemistry and Biotechnology from Ghent University in 2023. During her Master thesis in the lab of Prof. Frank Van Breusegem (VIB-UGent PSB), she focused on the role of cysteine oxidative post-translational modifications, more specifically protein sulfinylation, and the role of sulfiredoxin in the oxidative stress response in plants. After her Master thesis, she started in the lab of Prof. Bert De Rybel (VIB-UGent PSB), working on the Plant Single Cell Platform. During her time on the platform she gained novel knowledge and skills using single cell and single nuclei transcriptomics technologies. Later in 2024, Lindsy started her PhD journey in the group of Prof. Inge De Clercq (VIB-UGent PSB) where she studies the post-translational regulation mechanisms of membrane-bound transcription factors during mitochondrial retrograde signaling.

Elena obtained her PhD in 2021 under the supervision of Dr. Pilar Cubas at the National Centre for Biotechnology (CNB-CSIC) in Madrid, Spain. Her research focused on strigolactone signalling in Arabidopsis, specifically studying the degradation of the strigolactone receptor AtD14 and its role in plant development. After completing her PhD, she joined Prof. Inge De Clercq’s lab, which focuses on Inter-organelle Stress Signalling, as a postdoctoral scientist. Currently, Elena holds a Marie Curie Postdoctoral Fellowship, aiming to unravel the interactions between chloroplasts, the endoplasmic reticulum (ER), and mitochondria, with the goal of identifying the complex molecular mechanisms involved in inter-organelle communication.

Inter-organelle Stress Signalling

To be able to survive constantly changing and often harmful environmental conditions, plants must continuously adapt. Therefore, plants have complex mechanisms that sense and transduce environmental stimuli into adaptive and defence responses. Organelles within the cell are thought to be important sensors of such stresses, such as water limitation or pathogen attack. They communicate their stressed status with the nucleus to activate tolerance mechanisms and defence responses against the incoming stresses. We have previously revealed a novel mechanism of how mitochondria, chloroplasts, and the endoplasmic reticulum communicate stress signals to coordinate stress signal transduction into adaptive responses in the nucleus. However, we still lack a profound mechanistic understanding of how organelles cooperate with each other during stress responses. The signalling sources within the organelles, their release and/or propagation, and their perception by other organelles and eventually by the nucleus are still enigmatic. Therefore, the Inter-organelle Stress Signalling team performs studies to understand the complex organelle-organelle and organelle-to-nucleus cross-talk using high-end multi-omics and cell biology approaches.